The HC-II Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SERPIND1. This antibody recognizes Human, Mouse, and Rat antigen. The HC-II Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Post-translational Modifications: Phosphorylated by FAM20C in the extracellular medium.
Similarity: The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition. Belongs to the serpin family